UterineAdeTM

 

Composition:
Each 100 cc contains 20 grams of mannose and other monosaccharide sugars; 0.85 grams of sodium chloride, natural trace essential minerals from sea salts, buffered with sodium salts of organic acids and purified water.

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Action:
The principle of this monosaccharide solution is based on research which showed normal bacterial flora utilized monosaccharide metabolites to naturally inhibit pathogenic bacteria of the skin and mucous membranes1. Further research demonstrated that these monosaccharide sugars and their metabolites may be used to inhibit common pathogenic bacteria and fungi of the reproductive tract of mares. Research by other workers has confirmed that specific sugars can indeed prevent pathogenic bacteria from infecting mucosal and epithelial cells of the reproductive tract of mares 2. Also, it has been proven that that adequate sodium is essential for optimum reproductive fertility. An increase in sodium in the cervico-vaginal mucus is required during estrus for high conception rates3. A deficiency in sodium increases infertility and embryonic mortality 4,5. UterineAde solutions contain natural sodium sea salts.

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Indications:
For post foaling or aborting infected mares, the product may be used with other fluids and antibiotics. For the most efficient use of the product, other fluids such as saline lavage solutions may be used to remove debris from the uterus. After the debris and fluid are removed, infuse the uterus with undiluted UterineAde. UterineAde will promote the contraction of the uterus and will aid in clearing the uterus of excessive fluid. Use UterineAde daily until the uterus returns to normal.

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Dosage and administration:
For post-foaling and infected mares, 100 to 500 cc intrauterine, undiluted, per day, repeat daily until infection clears. For mares to be bred, 60 to 100 cc per day on the first day of estrus, repeat daily if necessary. Do not use the day of breeding. May be used 24 to 48 hours post-breeding.

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This protocol will aid in the prevention of venereal bacterial infections. This product has been formulated to be used without antibiotics. However, systemic antibiotics and other conventional treatments are recommended in addition to UterineAde if post foaling or aborting mares are infected with pathogenic microorganisms to aid in the prevention of septicemia and laminitis.

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Although UterineAde can be used without antibiotics, it can also be used in conjunction with antibiotics to aid in the healing of lesions while neutralizing microbial organisms. UterineAde will neutralize the microbial organisms if the bacteria are resistant to the antibiotics and may also allow antibiotics to be more effective. UterineAde not only will neutralize pathogens, but has the added benefit of healing lesions in the uterine mucosa.

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Caution:
For veterinary use only. Not to be used on animals intended for food. Keep out of the reach of children.
 Side effects: There are no known side effects.

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UterineAde may be used in combination with antibiotics to treat and prevent antibiotic resistant bacterial infections in mares and stallions.

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UterineAde was originally developed to treat and prevent bacterial infections caused by Taylorella equigenitalis, the causative organism for contagious equine metritis.  The overuse of antibiotics and potent disinfectants to treat T. equigenitalis,and similar pathogens caused bacteria to become antibiotic resistant leading to super bacterial infections.  Seemingly, when bacteria become resistant to antibiotics, they are more pathogenic and induce severe diseases of various tissues and organs including the reproductive tract.  Mares carrying these antibiotic resistant bacteria are not only more difficult to get pregnant, but may also spread venereal bacteria to stallions.  Then these antibiotic resistant venereal bacteria may spread to other mares.

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UterineAde, containing monosaccharide antibacterial and antifungal metabolites, naturally inhibits pathogenic bacteria without affecting the normal flora.  And, these natural antibacterial metabolites will not cause antibiotic resistance and super bacterial infections.

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H. Libor DVM in the Check Republic first demonstrated that UterineAde will change antibiotic resistant bacteria to become sensitive to commonly used antibiotics.  Other veterinarians and local equine practitioners later confirmed these findings.

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Mares infected with various antibiotic resistant bacteria, and failing to conceive while infected with these bacteria, Dr. Libor found that after treating these mares with UterineAde for up to 4 days, the antibiotic resistant pathogenic bacteria present in the reproductive tract then became sensitive to commonly used antibiotics, like penicillin and gentamicin.  Then after short cycling these mares, they were treated with UterineAde in combination with an antibiotic, like penicillin, before and after breeding.  This treatment was successful in the mares becoming pregnant.

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These results suggest that UterineAde may be used to enhance the activity of many antibiotics, especially for bacterial infections that are resistant to antibiotics.

 

Antibiotic sensitive discs with and without UterineAde.  The bacteria in the Petri dish are methicillin-resistant Staphylococcus aureus.